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As a complex protein, insulin synthesis involves multiple folding and modification steps, necessitating a highly developed rough endoplasmic reticulum (RER) in β-cells to support efficient protein synthesis and processing (Lee et al., 2015
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As a by-product, this process produces free radicals or reactive oxygen species (ROS), reactive nitrogen species (RNS), and carbon- and sulfur-centered radicals (Pero et al., 1990)
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