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In diet-induced obese mice lacking RAMP1 and RAMP3, cagrilintide’s potency was reduced and its activation of area postrema neurons was 57% lower than in wild-type mice, which the investigators interpreted as dependence on AMY1 and AMY3 receptors (Carvas et al., 2025)
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The Role of l-Carnitine in Mitochondria, Prevention of Metabolic Inflexibility and… [PMID: 35269860] Laboratory literature summary: The Role of l-Carnitine in Mitochondria, Prevention of Metabolic Inflexibility and Disease Initiation
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