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An example is the microtubule binding protein stathmin-2 (STMN2), which exhibits reduced expression due to TDP-43 mislocalization [202] and is currently being targeted by an antisense oligonucleotide in clinical trial
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In our earlier studies, we found a significant decrease in GSH in T2D individuals, and among 12 different markers of OS measured, GSH impressively correlated with changes in HbA1c [27], suggesting that altering hyperglycemia rapidly results in changes in GSH
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