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21 Three clinical trials, one open-label and uncontrolled, 22 one open-label and placebo controlled, 23 and one double-blind and placebo controlled, 24 investigated a multi-nutrient formulation containing NAC 1200 mg per day (other nutrients: folate, vitamin B12, alpha-tocopherol, S-adenosyl methionine and acetyl-L-carnitine) for 3−12 months in patients with Alzheimer’s disease, and found significant benefits in Dementia Rating Scale and clock-drawing tests as well as in assessments by caregivers in those receiving the multi-nutrient supplement versus placebo or versus baseline