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The Folin-Ciocalteu assay for total phenolic content has been used to show that green tea contains roughly 300 mg/g (expressed as EGCG) of dried leaves [38]
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This includes developing bifunctional molecules (e.g., Fer-1 conjugated to Nec-1, a necroptosis inhibitor) that co-target complementary pathways or epigenetic editing tools (e.g., dCas9-SunTag-KRAB systems) to dynamically suppress the transcription of ferroptosis–necroptosis crosstalk nodes (e.g., RIPK3)
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