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The gradient of lowered gene expression levels occurring in these mice has similarities to the patterns of altered gene expression that may occur, for example, in patients with unique SNPs or other defined or unknown genetic abberations (see for example and The allelic p53 “knock-down” series described by Hannon and colleagues represents an important example of how these “hypomorph” lines of mice provide novel models of human disease (Hemann 2003))

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