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In turn, transforming growth factor-β (TGF-β) expression by astrocytes inhibits NFκB signaling, helping to modulate and reduce the neuroinflammatory response ( Molecular and morphological changes during astrogliosis assessed by glial fibrillary acidic protein (GFAP) expression are directly related to the severity of astroglial reactivity, being GFAP overexpression a characteristic sign of neuroinflammation in neurodegenerative processes in the CNS (Sofroniew, 2009)
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