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471 Knocking down FTH in cardiomyocytes prevents free iron from being stored in ferritin, increases unstable iron pools, promotes intracellular ROS production, activates oxidative stress, and causes ferroptosis in cardiomyocytes, leading to age-related heart damage
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Realizing the potential of these multi-target agents will depend on sustained interdisciplinary collaboration to bridge laboratory findings and clinical applications
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