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Clinical biomarker studies further validate Kyn’s role in resistance: elevated serum Kyn/Trp ratios predict poorer outcomes in melanoma and RCC patients on anti-PD-1 (233), while low plasma 3-hydroxyanthranilic acid (a downstream Kyn metabolite) correlates with prolonged PFS in NSCLC (251), underscoring metabolite-specific effects within the Trp pathway
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Size:20x2 ml
Cel 55, 253–263
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US$40
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