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315,316 In a mouse asthma model, transgenic overexpression of Trx significantly reduced MIF expression in the airway epithelial cells and reduced the number of MIF-positive inflammatory cells in the lung parenchyma

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δ H (400 MHz, MeOD): 4.77 (1 H, dd, J = 9.5, 4.4 Hz, H-4), 4.04 (1 H, t, J = 6.3 Hz, H-1), 3.90 (1 H, d, J = 17.7 Hz, H-6 A or B ), 3.85 (1 H, d, J = 17.7 Hz, H-6 A or B ), 3.48–3.36 (4 H, m, PCH 2 + H-7), 3.32–3.25 (1 H, m, H-5 A or B partially obscured by residual peaks in NMR solvent), 3.24–3.15 (2 H, m, H-8), 2.95 (1 H, dd, J = 13.9, 9.5 Hz, H-5 A or B ), 2.58 (2 H, t, J = 7.1 Hz, H-3), 2.31–2.11 (2 H, m, H-2), 1.78–1.65 (2 H, m, CH 2 ), 1.65–1.52 (4 H, m, CH 2 )