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Oral and Topical Glutathione Generally well tolerated in short-term studies Mild side effects reported, including gas and loose stools Limited data on long-term safety, drug interactions, and use during pregnancy Bioavailability varies by formulation, with liposomal and sublingual products showing promise in small trials IV Glutathione IV glutathione, especially when used for cosmetic skin lightening, carries much bigger risks

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Guan F, Titt U, Bangert M, Mohan R