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Hybrid Harms Feature #3: Prolonged Spike Exposure and Antigenic Load Stability of the mRNA product is enhanced by LNP encapsulation and substitution of uridine with N1-methylpseudouridine, which minimizes degradation of the synthetic mRNA, thus ensuring the spike protein’s persistent bioavailability for an unknown period of time

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In summary, our results demonstrated that TG2 in cell lysates causes GST aggregate formation through crosslinking activity, which interferes with pulldown experiments and alters fused protein function