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According to researchers like Imiołek and colleagues (2025), ion exchange chromatography is a crucial analytical technique for ensuring “batch-to-batch repeatability and reproducibility, short- and long-term stability under different storage conditions, and detection and quantification of impurities, contaminants, and degradation products.” It is also valuable in characterizing biotechnology-derived products, including monoclonal antibodies (mAbs) and, more recently, cell and gene therapy products like messenger ribonucleic acid (mRNA) and adeno-associated viruses (AAVs)