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The honest conclusion: ✅ Interesting metabolic mechanism ✅ Promising results in mouse research ❌ Not clinically proven for human fat loss ❌ No established 150 mg human protocol ❌ Not FDA-approved Mouse data can identify a promising research direction—but it cannot establish a safe human dose

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We aimed to address the following topics in the consensus: (1) clinical manifestations of B12 deficiency (neurological and hematological endpoints), (2) risk groups, (3) causes of B12 deficiency, (4) laboratory diagnosis of B12 deficiency, and (5) treatment and long-term management of the deficiency