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ROS are oxygen‐containing chemical species that are generally classified into two main types [1]: free radical ROS, including superoxide anion (O2·‐), hydroxyl radical (·OH), alkoxyl (OOR), and peroxyl radical (OOH)

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Recent innovations in LNPs, particularly those integrating pH-sensitive or cationic helper lipids, have demonstrated effective mRNA delivery to pancreatic β-cells, resulting in transient but therapeutically relevant protein expression following systemic or intraperitoneal administration

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