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If the “thought experiment” is performed whereby APAP is considered as a recent compound that was being progressed through drug development today, it would be clear that it is reproducibly hepatotoxic at high doses in laboratory species, but that there are marked species differences in sensitivity (mouse ≫ rat)

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Dysautonomia Autonomic dysfunction (dysautonomia) describes any malfunction in the autonomic nervous system, especially the vagus nerve [115,116], which is a key element in (but not synonymous with [117]) POTS, and the occurrence of dysautonomia broadly mirrors the diseases in which POTS is known to occur (Table 2)