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Central tolerance is established during T cell development in the thymus, with thymocytes expressing T cell receptors (TCR) of too high affinity for self-antigen/MHC complexes eliminated (negative selection) [10]
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The hepatic response to the accumulation of damaged cellular proteins, nucleic acids, and lipids impairs cellular functions and stimulates the induction of pathways, such as the unfolded protein response or the endoplasmic reticulum (ER) stress response
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