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These effects were associated with the inhibition of NF-κB nuclear translocation and reduced phosphorylation of κB and mitogen-activated protein kinases, including p38, extracellular signal-regulated kinases 1 and 2 (Erk 1/2), and c-Jun N-terminal kinase (282)
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Recognition of danger signals released from failing or malfunctioning cells, leading to production of mature IL-1β, is a key event in this process 15
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