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Important NHS prescribing conditions include: Treatment must be initiated and supervised by a specialist weight management service Treatment should only continue if at least 5% of total body weight is lost after 12 weeks at the maintenance dose For semaglutide (Wegovy), treatment should not continue for longer than 2 years Documented evidence of previous weight loss attempts through diet and exercise Engagement with a structured weight management programme Commitment to ongoing lifestyle modifications Women with PCOS who have developed type 2 diabetes may be eligible for GLP-1 medications through diabetes treatment pathways, which have separate prescribing criteria

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