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Each stacked unit was composed of two cis -dimers and two allo -dimers, forming an octameric assembly that extended into filaments through interactions mediated by the oligomerization loop ( Figure 5D )
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Among the series, compound with bromo atom and two hydroxyl groups in the 3-phenylcoumarin moiety ( 14 ), was identified as a best inhibitor with an IC 50 value of 215 μM
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