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It is possible to have adequate levels of the vitamin in the bloodstream, but this is meaningless if our bodies are unable to engage the metabolic pathways required to utilize the vitamin (as seen in individuals with genetic MTHFR mutations)

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The outputs of pMet and pMet i were only affected by parameters directly modulating Met or α5β1 integrin, evident by the cluster of parameters in the bottom middle section of the heatmap (Fig