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Conclusion In this work, we investigate a variety of approaches for predicting aqueous solubility and pH–solubility curves, with the goal of leveraging recent advances in pretrained molecular representations and macroscopic p K a predictions to achieve superior performance
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Disease states that affect intra-portal insulin levels by increasing insulin resistance causing compensatory intra-portal hyperinsulinemia or by decreasing pancreatic β-cell insulin secretion causing intra-portal hypoinsulinemia results in changes to hepatic IGF-I synthesis and secretion, and consequently changes in GH levels via the negative feedback loop
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