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There is possible evidence that PKC, which is stimulated in diabetes via multiple mechanisms activates NAD (P) H oxidase (Amiri et al ., 2002) Natural Defense Against Oxidative Stress and Antioxidants in Diabetes Reactive species can be eliminated by a number of enzymatic and nonenzymatic antioxidant mechanisms
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Future perspective With multiple proposed mechanisms for analgesic effect, future studies should focus on larger scale, randomized controlled trials to further describe both efficacy and safety in the acute perioperative patient
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