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does glutathione have arginine L-arginine mitigates against cisplatin-induced defective cardiac metabolic flexibility by activating Nrf2/HO-1 and upregulating in male Wistar rat DOD – Unlock Funding
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Similarly, previous studies showed that CAT1 was induced by benzoquinone and hypochlorous acid, which are oxidizing agents that also cannot be acted on by catalase [3]
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Furthermore, this intrinsic link between efficacy and pharmacological side effects highlights a major challenge in current development efforts for conventional NMDAR antagonists, including reformulations and analogues of esketamine
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