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Other contributors to poor methylation: medications yeast elevated estrogens high histamine diet stress Lipopolysaccharides from bacterial infections (LPS)¹⁵ heavy metals¹⁶ ¹⁷ inflammation¹⁸ alcohol¹⁹ It must be noted that there is the possibility of hyper methylation or hypo methylation, where the methylation pathway is sped up or slowed down, respectively

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