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Because the endoplasmic reticulum, along with the Golgi system, is also responsible for normal cellular detoxification, these de novo mutations may make individuals less able to tolerate injected neurotoxins including methyl mercury from dental amalgams from their mothers, ethyl mercury from thimerosal (in some flu vaccines) and aluminum, which is found in many vaccines on the CDC schedule as an adjuvant in the form of aluminum hydroxide, which also impairs mitochondrial function [29-33]

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Rac2 −/− PMNs isolated from mice have a defect in superoxide production, where production is restored upon reintroduction of wild-type Rac2 using retrovirus-mediated gene transfer (Filippi et al., 2004)