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The intrinsic pathway is commonly triggered via members of the B cell lymphoma 2 (Bcl-2) family, which control mitochondrial outer membrane permeabilization, cytochrome c release, and, subsequently, caspase activation (11)
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Decarboxylated SAM (dcSAM, formed by SAM decarboxylase) donates aminopropyl groups sequentially: spermidine synthase adds one aminopropyl group to putrescine to form spermidine, and spermine synthase adds a second to form spermine
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