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a low ratio decreases IL-12 secretion which favors a Th2 response pattern over Th1 (a condition typically associated with chronic inflammation), while an elevated ratio favors a Th1 response ( The glutaredoxin (Grx) system, another key player, operates in close association with the GSH pool and serves primarily to regulate protein thiol redox status through reversible de-glutathionylation
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Succinate is an important substrate of complex II that accumulates and is rapidly oxidized by complex II upon ischemia/reperfusion, thus leading to the accumulation of large amounts of O 2 •− in complex II [50,120]
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