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TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains: Molecular Cell
With its favorable safety profile, spermidine supplementation could offer a viable option for managing neuropathic pain, although further research is needed to determine its mechanisms of action and optimal usage in human subjects [198]
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Among hit candidates discovered from this structural-based virtual screening and further chemical optimizations, GiGA1 (G protein-independent GIRK activator 1) exhibited high specificity for activating GIRK1/2 channels and demonstrated significantly higher potency than ethanol (EtOH), with an EC 50 of 31 μM (Zhao et al., 2020), with excellent brain penetration (Table 1)
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