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Evidence indicates that the role of mTOR is to regulate the gene expression of the enzymes for the glycolysis pathway and modulate the enzymatic activity through phosphorylation, promoting the appropriate microenvironment for cancer cell growth and development (58)
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Furthermore, colorectal cancer was diagnosed in three of 34 small-duct PSC patients (10%) in contrast to 11 of 206 large-duct PSC patients (5%)
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