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10.1016/j.cortex.2015.08.022 Keywords VX Drug Class: Chemical Warfare Agent classified as a Nerve Agent Mechanism of Action & Effects: Routes of exposure: VX can be absorbed through the eyes or the skin of the victim As little as one drop of VX on the skin can be fatal (as compared to 1 to 10 mls of sarin or soman) The LD50 for humans is estimated to be ~10 mg Notes: Amber (honey brown) ♦ colored, tasteless & odorless, oily liquid with low volatility unless temperatures are high The “V” of VX signifies it very long persistence compared to sarin and soman VX decomposes at a rate of ~ 5% a month at 71 °C VX-inhibited cholinesterase can be reactivated by 2-PAM for as long as 48 hours (Sidell & Groff : The reactivatibility of cholinesterase inhibited by VX and sarin in man

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The main contributors to ROS production in this organelle are members of the cytochrome P450 family and the combination of the protein disulfide isomerase PDI and the endoplasmic reticulum oxidoreductin-1 (ERO1)

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