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Notably, a sub-toxic dose of functional food nutrients such as flavonoids and their metabolites, particularly polyphenol nanoparticles, can induce neurohormesis, triggering adaptive neuronal stress responses driven by the modulation of phase II resilience genes and proteins, such as Hsp70, HO-1, GSH, histone deacetylases of the sirtuin family, lipoxin A4 (LXA4), neurotrophic factors such as brain-derived neurotrophic factor (BDNF) and transcription factors of the forkhead (FOXO) family