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"type 1" or "M1-like" monocytes and/or macrophages are monocytes and/or macrophages capable of contributing to a pro-inflammatory response, characterized by at least one of the following: the production of inflammatory stimuli by secretion of at least one pro-inflammatory cytokine, expression of at least one cell surface activating molecule/activating molecule ligand on its surface, recruitment/guidance/interaction of/with at least one other cell (including other macrophages and/or T cells) to stimulate a pro-inflammatory response, presentation of an antigen in a pro-inflammatory background, migration to a site that allows for the onset of a pro-inflammatory response, or initiation of expression of at least one gene that is predicted to produce a pro-inflammatory functionality