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doi: 10.1111/tpj.15437 149 TianR.Nájera-GonzálezH.-R.NigamD.KhanA.ChenJ.XinZ.et al
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In sALS patients, deregulation of the cellular redox systems has been suggested by higher free radical levels found in the blood and serum of patients[32, 73], and evidence of oxidative damage includes the increase in protein carbonyls[34, 35, 74, 75], 8-OHdG[47, 49], MDA-modified proteins[34], 4-HNE protein conjugates[36, 76], and nitrotyrosine products[77–79] in the spinal cord
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