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The nitroimidazole prodrug Evofosfamide (TH-302) [493–496] releases alkylating agents upon reductive cleavage while concomitantly producing cytotoxic free radicals, synergistically exacerbating local oxidative damage
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In addition, GSTM3 has been reported to interact with TRAF6 in cervical cancer tumors similar to GSTP1-TRAF2 [68]
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