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When NAC is converted to cysteine, it is exchanged into the glia for glutamate, which provides inhibitory feedback on presynaptic receptors, thereby limiting the release of glutamate

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While local anesthetics provide analgesia by selectively suppressing pain perception at the periphery, general anesthetics act centrally to induce loss of consciousness, amnesia, and immobility through modulation of CNS receptors such as GABA-A and NMDA [64,65,66]