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compared clobetasol propionate oral gel 0.05% local treatment, niacinamide, oral probiotics and doxycycline four ways of treatment, found that the four ways to improve the symptoms of MMP patients were improved, corticosteroid, doxycycline, and nicotinamide are all good at controlling local reactions and inflammation, and probiotics can balance the dysbacteriosis of the oral cavity without adverse reactions, based on this evidence, let us focus on probiotics as an important adjunct to first-line therapy in the adjuvant and long-term treatment of MMP (82)