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Therefore, although children with various genetic conditions and neurodevelopmental disorders usually have normal GH secretion as assessed by the classical criteria for diagnosing GH deficiency (155), altered IGF-1 levels or actions in the various compartments of the central nervous system of these patients can significantly influence brain development and function
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This may justify the fact that these hormones are involved in the control of the synthesis and secretion of GH, a hormone with important metabolic actions: hyperglycemic, lipolytic, and anabolic, which is stimulated by ghrelin and inhibited by nesfatins
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