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The released Zn 2+ is subsequently sequestered by mitochondria, triggering mitochondrial fission and resulting in fragmentation and dysfunction

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Additionally, studies that examined the uptake of [ (11) C]-verapamil, a compound that is usually extruded from the brain by P-gp, demonstrate a significant elevation of [ (11) C]-verapamil in PD patients compared to controls [213, 214] suggesting that P-gp dysfunction contributes to PD pathogenesis [213, 214]