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The FDA informed medical experts that it had evaluated SAGhE (Sante Adulte GH Enfant) trial data in August 2011 (a long-term epidemiological study conducted in France)
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As tesaglitazar decreased SIRT1 expression and increased Ac-PGC1α levels, we assessed whether pharmacological activation of SIRT1 by resveratrol and eventually PGC1α would alleviate cardiac toxicity driven by dual PPARα/γ activation
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