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Other studies also revealed that CRC subpopulations associated with more favorable prognosis exhibit elevated expression levels of chemokines such as chemokine (C–C motif) ligand (CCL) 5, chemokine (C–X–C motif) ligand (CXCL) 9, and CXCL10 as well as cytokines such as interleukin (IL)-7, IL-8, IL-15, IL-18, and IL-1β that promote the immune inflammatory profile as compared to other CRC subpopulations
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