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Mutation of allosteric hot spot residues alter the allosteric communications In order to examine how the triangular allosteric network responds to the mutations of key residues, we have prepared three GDH mutants in silico using Chimera rotamers tools 29 GDH Ser441Leu , GDH Arg217Cys , and GDH Gly376Asp
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Larger and longer-term clinical trials are needed, and supplementation with other compounds important for methionine metabolism, such as vitamin B6, should be considered in ALD patients
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