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This may be the result of decreased plasma levels of thyroid hormones and recovery from euthyroidism, but the antioxidant effect of thiamazole should also be considered.15 We found that in vitro treatment of PBMC from patients with Graves’ disease with NAC (2mM) significantly reduced intracellular ROS levels after 24hours of culture due to its action as precursor to reduced glutathione synthesis or as direct scavenger of ROS.16 In Graves’ disease, an increase in ROS has been reported in the thyroid, blood tissue, and periorbital tissue of patients with orbitopathology,5–8 but the increase in ROS in PBMC has not been previously described

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10.1146/annurev-marine-121211-172346 [DOI] [PubMed] [Google Scholar] Tripathi D, Mani V, & Pal RP (2018)