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Other commonly used “second-line agents” include: Azathioprine, Leflunomide, and Mycophenolate Mofetil, however, the evidence behind these latter medication recommendations is very weak ( For patients with symptomatic pulmonary sarcoidosis believed to be at higher risk of future mortality or permanent disability from sarcoidosis who have been treated with glucocorticoids or other IST and have continued disease, the guidelines suggest the addition of infliximab to improve and/or preserve lung function and HRQoL (49–62) and extra-pulmonary sarcoidosis (49, 63)

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