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Within the innate immune response, NLRP3 inflammasomes, innate immune components expressed by macrophages and microglia, mediate caspase-1 activation and promote the secretion of pro-inflammatory cytokines within the CNS, thereby contributing to both systemic and neuroinflammatory responses (36, 37)
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Impeding the combination of astrocytic ASCT2 and NLRP3 by talniflumate alleviates neuroinflammation in experimental models of Parkinson's disease
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