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Both malondialdehyde (MDA) and 4-hydroxy-2-nonenal (4-HNE) are reactive aldehyde–lipid peroxidation by-products (see Figure 2) that have been widely used as biomarkers of OxS [59,60]
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Lipoyl adducts formed by changes in oxidative or catabolic stress can alter TCA cycle function to allow the cell to adapt to these insults, as demonstrated for transient lipoyl nitrosylation during macrophage activation 15,33
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