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These statistics emphasize the global burden of MASH on health care ( The strong association between obesity and MASH has established a conceptual framework in which increased adiposity is considered a main driver of hepatic fat accumulation and disease ( Current therapeutic strategies for MASH are based on a metabolic-centric framework, with weight reduction as the primary intervention ( The progression from simple steatosis to MASH comprises complex bidirectional metabolic and immune interactions ( 2 The systemic and immunometabolic nature of MASH 2.1 Determinants of hepatocellular injury and the inflammatory response The development of MASH results from the interaction of systemic and hepatic factors that promote metabolic dysfunction in the liver and trigger an inflammatory response

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