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HIF-1 is a heterodimeric transcription factor constituted by two subunits, the regulatory hypoxia response factor HIF-1Ξ±, and the constitutive receptor nuclear translocator HIF-1Ξ² ( Figure 1 Low oxygen levels lead to accumulation of HIF-1Ξ±, which can translocate to the nucleus and form a dimer with the Ξ² subunit
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