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For example, ER stress can promote acinar cell apoptosis by activating the p53/AIFM2 axis and the PERK–JNK pathway, 252,253,254,264 induce caspase-1-dependent pyroptosis via activation of the PERK pathway, 265 and trigger necroptosis in pancreatic acinar cells by enhancing CTSB maturation and activating the PKCα–JNK–c-Jun cascade

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doi: 10.1016/j.bbapap.2011.10.001