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Table of Contents Lyme disease is a vector-borne illness primarily transmitted to humans through the bite of infected black-legged ticks

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Many of the pathogens share common features associated with macrophage survival and replication, such as cell-surface modification strategies (SOWgp, α-glucan, Rod A, polysaccharide capsule), to avoid pathogen recognition and ultimately phagocytosis and ROS resistance (superoxide dismutases and catalases, polysaccharide coat), reducing the antimicrobial activity of the macrophage and the utilization of alternative nutrient-acquisition pathways to enable survival within the nutrient-sparse macrophage environment